Isoforms of renal Na-K-2Cl cotransporter NKCC2: expression and functional significance
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چکیده
منابع مشابه
Osmoregulation requires brain expression of the renal Na-K-2Cl cotransporter NKCC2.
The Na-K-2Cl cotransporter 2 (NKCC2) was thought to be kidney specific. Here we show expression in the brain hypothalamo-neurohypophyseal system (HNS), wherein upregulation follows osmotic stress. The HNS controls osmotic stability through the synthesis and release of the neuropeptide hormone, arginine vasopressin (AVP). AVP travels through the bloodstream to the kidney, where it promotes water...
متن کاملPhysiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2).
The Na-K-2Cl cotransporter (NKCC2; BSC1) is located in the apical membrane of the epithelial cells of the thick ascending limb of the loop of Henle (TAL). NKCC2 facilitates ∼20-25% of the reuptake of the total filtered NaCl load. NKCC2 is therefore one of the transport proteins with the highest overall reabsorptive capacity in the kidney. Consequently, even subtle changes in NKCC2 transport act...
متن کاملDietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2.
Both sodium reabsorption in the thick ascending limb of the loop of Henle (TAL) and macula densa salt sensing crucially depend on the function of the Na/K/2Cl cotransporter NKCC2. The NKCC2 gene gives rise to at least three different full-length NKCC2 isoforms derived from differential splicing. In the present study, we addressed the influence of dietary salt intake on the differential splicing...
متن کاملRenal Expression and Urinary Excretion of Na-K-2Cl Cotransporter in Obstructive Nephropathy
Renal damage due to urinary tract obstruction accounts for up to 30% of acute kidney injury in paediatrics and adults. Bilateral ureteral obstruction (BUO) is associated with polyuria and reduced urinary concentrating capacity. We investigated the renal handling of water and electrolytes together with the renal expression and the urinary excretion of the Na-K-Cl cotransporter (NKCC2) after 1 (B...
متن کاملIsoforms of the Na-K-2Cl cotransporter in murine TAL I. Molecular characterization and intrarenal localization.
We have identified several alternatively spliced cDNAs encoding mBSC1, an apical bumetanide-sensitive Na+-K+-2Cl-cotransporter from mouse kidney. Two full-length clones were isolated, designated C4 and C9, predicting proteins of 770 and 1,095 amino acids, respectively. The C4 isoforms are generated by utilization of an alternative polyadenylation site located within the intron between exons 16 ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2008
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00106.2008